Bromocriptine Book

About the Book (Words from the author)About the Book

Bromocriptine is a dopamine agonist drug (meaning that it acts like dopamine in the brain) that has been used for over three decades for the treatment of a number of conditions such as Parkinson's disease, acromegaly (the disease Andre "The Giant" had), and overproduction of the hormone prolactin. You may be wondering what this has to do with the topic of body composition.

As I discuss in many of my articles and other books, the body regulates factors such as body weight, composition and appetite through a variety of hormones such as insulin and leptin. It turns out that those hormones exert at least part of their effect through dopamine levels in the brain. When people diet, dopamine levels drop in the brain and this is responsible for many of the effects (such as lowered metabolic rate, increased hunger, etc.) that occur.

My book Bromocriptine starts by outlining the systems that regulate body weight and fat levels before explaining how the drug bromocriptine can ‘trick' the body into thinking that it's not dieting so that metabolic rate doesn't slow, hunger is decreased, etc. Side effects, dosing and everything else related to the drug and how it can be used for various purposes related to body composition are outlined in detail in the book.

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Table of Contents Chapter 1: Defining the Problem Chapter 2: How your Body Knows Chapter 3: Leptin Resistance Chapter 4: Bromocriptine Chapter 5: What Bromocriptine Does Chapter 6: How Bromocriptine Works Chapter 7: Using Bromocriptine, Part 1 Chapter 8: Side-effects and Risks Chapter 9: Using Bromocriptine, Part 2 Chapter 10: Miscellaneous Miscellany Appendix 1: The FDA and Bromocriptine Frequently Asked Questions References Cited

Excerpt from this book

The following is from Chapter 4: Bromocriptine

The effects of bromocriptine in the brain are complex and different sources give slightly different descriptions. To avoid utter confusion on the part of myself and the readers, I'm only going to focus on bromocriptine's primary mode of action, which is as a dopamine 2 (D2) receptor agonist (30). Bromocriptine is also a weak antagonist at the D1 receptor. Now that youre totally confused, let me explain what it means to be a D2 receptor agonist or a weak D1 receptor antagonist.

An agonist is any drug or compound that stimulates a specific receptor. So, in the same way that a hormone/neurotransmitter will bind to the receptor and make 'stuff happen', an agonist drug does the same.

An antagonist is the opposite of an agonist. It is a drug that binds to a receptor without sending the normal metabolic signal. But it's more than just neutral. At the same time that it binds the receptor without sending a signal, it also prevents other compounds (such as DA itself) from binding.

As a D2 receptor agonist drug, bromocriptine will bind to the D2 receptor and cause an effect similar to if DA itself had bound. It also has weak antagonistic effect at the D1 receptor, which aren't that important in the big scheme of things. As a weak D1 antagonist, bromocriptine binds to the D1 receptor a little, preventing normal binding of DA a little. I won't really talk too much about this effect since it seems fairly unimportant in the big scheme of things.

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